‏ intro ‏ case ‏ background ‏ making diagnosis ‏ pathophysiology ‏ Management Principals ‏ Management Algorithm ‏ Development ‏

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CASE HISTORY


Hb 11.5, WCC 4.3, Platelets 50.
Na 136, K 3.4, urea 6.2, creatinine 138.
PT (prothrombin time) >180, APTT (activated partial thromboplastin time) >240, INR 12.

Hb 11.5, WCC 4.3, Platelets 50.
Na 136, K 3.4, urea 6.2, creatinine 138.

Diagnosis: meningococcal septicaemia.
Bloods sent for FBC, biochemistry, U&E, clotting.



(click for larger graph)

Diagnosis: meningococcal septicaemia.
Bloods sent for FBC, biochemistry, U&E, clotting.



(click for larger graph)

Diagnosis: meningococcal septicaemia.
Bloods sent for FBC, glucose, biochemistry, U&E, clotting.

15 year old  boy non-specifically unwell for a day.  Woke with a widespread purpuric rash and taken straight to hospital.

(click for larger graph)


ED assessment:
Temp 39.0, HR 120, RR 20, BP 90/60.
Alert no meningism; purpuric rash spreading.


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QUESTIONS ON CASE 4


     Q 7 of 18: An LP was done during the second hour after admission. Was this appropriate given the clinical signs and the fact that clotting results were not yet available?

Yes <incorrectNo

INCORRECT : An LP was absolutely contraindicated: this was an ill child with a widespread purpuric rash which is strongly suggestive of coagulopathy (this was later confirmed on blood tests).
Further Information

Lumbar Puncture

Lumbar puncture can be important for treatment if the clinical diagnosis is in doubt particularly, in children who are febrile without a focus. For children with obvious meningeal symptoms, microbiological confirmation is valuable for

  • duration of treatment
  • decisions about prophylaxis and public health management,
  • follow up care of children who recover with neurological sequelae, and
  • disease surveillance.

However, LP must not be performed when there are contraindications and should never delay treatment. With modern PCR techniques, CSF samples may still be positive after antibiotics have killed the organisms.
Check with a senior colleague if you are unsure.


Before attempting lumbar puncture assess HR, RR, BP, CRT, pupils, rash, fundal examination for papilloedema.
Make sure there are no signs of raised intracranial pressure or shock.


The APLS Contraindications to Lumbar Puncture 30
  • Prolonged or focal seizure
  • Focal neurological signs ( including ocular palsies)
  • Widespread purpuric rash in ill child
  • Glasgow coma score <13
  • Pupillary dilatation
  • Impaired oculocephalic reflexes
  • Abnormal posture
  • RICP: inappropriately low pulse, elevated blood pressure and irregular respirations. (indicating impending brain herniation)
  • Coagulopathy
  • Papilloedema
  • Hypertension

Lumbar puncture should also be avoided where there is any cardiovascular or respiratory compromise or if there is local infection at the site of LP.


LOOK IT UP


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