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CASE HISTORY


Given ceftriaxone and 20mls/ kg bolus of albumin. Bloods taken for full blood count, glucose, electrolytes, biochemistry, clotting, blood culture, meningococcal PCR, blood gas to assess severity of metabolic acidosis.

The medical team used the Glasgow meningococcal septicaemia prognostic score to score the illness on presentation.

Diagnosis: meningococcal septicaemia with shock.

18:15 hours paediatric registrar and SHO
History taken as above; rash noted to be purpuric.
Initial examination (in oxygen): airway clear, good saturations, equal breath sounds, no crepitations. Heart rate fast at 143, capillary refill time 6 seconds at feet. Heart sounds: gallop rhythm. BP 114/72. Rash is spreading, now on legs as well. Responding to voice, no neck stiffness, equal pupils. Blood gas taken to assess the degree of metabolic acidosis: pH = 7.2, BE= - 9.

Case History
12 year old boy referred to hospital by his GP. He was found to be febrile & drowsy with a few non-blanching spots. The GP gave a dose of intra-muscular penicillin and sent him into hospital as an emergency.


18:00 hours ED triage
Fever for a day, generally unwell with headache, regular paracetamol during day. No urine output since very early morning. No neck stiffness or vomiting. Temperature not coming down, new rash on back, increasingly drowsy.

Observations: temp 39.5, pulse 148, RR40, Cold hands and feet. Sats 92% in air. Conscious level is V (AVPU scale). Widespread non- blanching rash on trunk

Nursing actions: probable meningococcal disease, put out emergency call for paediatrics. High-flow oxygen started via facemask. BM done = 6.5.


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QUESTIONS ON CASE 8


     Q 9 of 10: Adequate investigations?

YesNo <incorrect

INCORRECT : Full set of bloods taken.
Further Information

Initial laboratory assessment

The tests below should be done on all suspected cases of MD and children who are suspected of having an invasive bacterial infection:

  • Glucose
  • Full blood count
  • Electrolytes and urea
  • Calcium and magnesium ( metabolic derangements are common in septicaemia and may contribute to myocardial dysfunction)
  • Phosphate
  • Clotting studies
  • Venous blood gas to measure base excess
  • Blood culture
  • Throat swab culture
  • Meningococcal PCR whole blood (EDTA specimen) to send to reference laboratory

Parameter Normal range*
Hb 10.5 to 13.5 g/dL
WCC 5.0 to 15.0 (×109)
Platelets 150 to 450 (×109)
Base Excess 0 to -3 mmol/L
pH 7.35 to 7.45
HCO3 22 to 26 mmol/L
PaO2 10 to 13.5kPa or 75 to 100mmHg
PaCO2 4.6 to 6kPa or 34.5 to 45 mmHg
Glucose 3.6-5.2 mmol/L
Urea 2.5 to 6.0 mmol/L
Creatinine 19 to 43 mmol/L
Na 133 to 146 mmol/L
K+ 3.5 to 5.5mmol/l
Mg++ 0.66 to 1.0 mmol/L
Total Calcium 2.17 to 2.44 mmol/L
PO4 1.60-2.90 mmol/l
INR 1
PT 9.9 to 12.5 seconds
APTT 26.0 to 38.0 seconds
TT 9.2 to 15.0 seconds
Fibrinogen 1.7 to 4.0 g/L

*Please note that normal ranges for many variables can differ among hospitals.

Blood gas reports measurement of base excess (BE), which, when negative indicates that there is a base deficit (acidosis).


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