Diagnosis: possible meningitis or encephalitis

Loaded with phenytoin, 20 minutes later stopped fitting.

Further clinical assessment. Only responding to deep painful stimuli (AVPU), pupils size 7 slowly reacting, normal fundi. BP 140/85, HR 90

Case History
4 year old girl brought by ambulance following a prolonged seizure, which had begun 40 minutes earlier. Parents found her in the living room shaking all of her body and unresponsive to their voices. Immediately called 999 ambulance. The paramedic team have given diazepam rectally and she is on 100% oxygen.
Non-specifically unwell for several days with a cold and behaving quite irritably. Fever for 24 hours and vomited during the day - her parents have been giving her paracetamol. She has never had fits before and there is no family history of seizures.

Taken immediately to ED Resuscitation: Status epilepticus ? cause possible infection. ED SHO assessment immediately:

Airway self-maintained but guedel airway in situ inserted by paramedics. 100% oxygen with saturations of 100%. Air entry equal bilaterally. Well-perfused centrally.
Generalised tonic clonic seizure continuing. No rashes seen.

Observations: Temp 39.5, BP 130/80 (difficult to measure), Pulse 100, RR 56. Blood sugar 7.1.

Immediate intervention
i.v. access obtained X 2, bloods taken including blood cultures.
i.v. ceftriaxone and acyclovir commenced
Given IV lorazepam X 2 0.1mg/kg, failed to stop seizure